Blar i forfatter "Giles, Graham"

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    • Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival 

      Johansson, Mattias; Anouar, Fanidi; Muller, David C.; Bassett, Julie K.; Midttun, Øivind; Vollset, Stein Emil; Travis, Ruth C.; Palli, Domenico; Mattiello, Amalia; Sieri, Sabina; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Ljungberg, Börje; Hallmans, Göran; Weiderpass, Elisabete; Skeie, Guri; Gonzalez, Carlos A.; Dorronsoro, Miren; Peeters, Petra H.; Bueno-de-Mesquita, H. B(as).; Ros, Martine M.; Ruault, Marie-Christine Boutron; Fagherazzi, Guy; Clavel, Françoise; Sanchez, Maria-Jose; Gurrea, Aurelio Barricarte; Navarro, Carmen; Quirós, J. Ramón; Overvad, Kim; Tjønneland, Anne; Aleksandrova, Krassimira; Vineis, Paolo; Gunter, Marc J.; Kaaks, Rudolf; Giles, Graham; Relton, Caroline; Riboli, Elio; Boeing, Heiner; Ueland, Per Magne; Severi, Gianluca; Brennan, Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-05)
      The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. ...

    • Grain and dietary fiber intake and bladder cancer risk: a pooled analysis of prospective cohort studies 

      Yu, Evan Y W; Wesselius, Anke; Mehrkanoon, Siamak; Brinkman, Maree; van den Brandt, Piet; White, Emily; Weiderpass, Elisabete; Le Calvez-Kelm, Florence; Gunter, Marc; Huybrechts, Inge; Liedberg, Fredrik; Skeie, Guri; Tjonneland, Anne; Riboli, Elio; Giles, Graham; Milne, Roger L; Zeegers, Maurice P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-10)
      Background - Higher intakes of whole grains and dietary fiber have been associated with lower risk of insulin resistance, hyperinsulinemia, and inflammation, which are known predisposing factors for cancer.<p> <p>Objectives - Because the evidence of association with bladder cancer (BC) is limited, we aimed to assess associations with BC risk for intakes of whole grains, refined grains, and dietary ...

    • Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms 

      Gagliardi, Amedeo; Dugué, Pierre-Antoine; Nøst, Therese Haugdahl; Southey, Melissa C.; Buchanan, Daniel D.; Schmidt, Daniel F; Makalic, Enes; Hodge, Allison M; English, Dallas R.; Wong Doo, Nicole; Hopper, John L.; Severi, Gianluca; Baglietto, Laura; Naccarati, Alessio; Krogh, Vittorio; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Lund, Eiliv; Giles, Graham; Pardini, Barbara; Sandanger, Torkjel M; Milne, Roger L.; Paolo, Vineis; Polidoro, Silvia; Fiorito, Giovanni (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-11)
      <p>Background: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic epigenetic mutations (SEM) has been suggested as a biomarker of life-course accumulation of exposure-related DNA damage; however, the predictive role of SEMs in cancer has seldom been investigated. <p>Methods: A SEM, at a given CpG site, was defined as an extreme ...